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Age Aging is featured by an increase in serum levels of cytokines and acute phase proteins (APPs) due to a low-grade inflammatory status which may be induced by increased visceral adiposity, declined function of sex hormones, genetics, neurodegenerative disorders as Alzheimers disease (AD) or cardiovascular complications

Free Radical Biology and Medicine 37: 803812 doi:10.1016/j.freeradbiomed.2004.06.001 [DOI] [PubMed] [Google Scholar] 11

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The pace of free radical generation, however, can often surpass the cellular production of glutathione (GSH), leading to a cascade of oxidative stress, chronic inflammation and tissue damage

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